New PDF release: Angiostatin

By Icon Group International

Angiostatin protein is a proteolytic fragment of plasminogen that has been proven to inhibit endothelial mobilephone proliferation and migration in vitro and tumor angiogenesis in vivo.

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Professor; Boston Medical Center Gambro Bldg, 2Nd Fl, 660 Harrison Ave, Ste a Boston, Ma 02118 Timing: Fiscal Year 2001; Project Start 15-FEB-2001; Project End 31-JAN-2006 Summary: Control of fat cell mass and fat cell size may result from signals generated in the brain or from other tissues but ultimately cellular events transpire that are translated into partitioning of fuels in a regulated manner, presumably due to the particular enzyme and metabolite concentrations that are present. Evidence in support of this concept is derived from the observation that, despite ad libitum access to food, most mammals maintain a constant weight and constant fat mass.

Sodium-myo inositol cotransporter which transports the osmolyte myo-inositol. L-carnitine is another osmolyte that plays a key role in the adaption of hyperosmolality and is found in high concentrations in epididymal luminal fluid. Therefore, this study will examine how the transporter for L-carnitine, Novel Organic Cation Transporter 2 (OCTN2), plays a critical role in allowing epididymal cells to adapt to a hyperosmotic environment and ultimately protecting themselves from osmotic stress. Our working hypothesis is that osmotic stress of epididymal cells results in an influx of ions which increases the intracellular ionic strength.

The focus of the proposed studies is to understand regulation of partitioning of free fatty acids (FFA) between utilization (to produce energy or heat) and deposition (as triglyceride) in adipocytes and 32 Carnitine the impact of alterations in the putative key enzymes that regulate partitioning on fat accumulation. Partitioning between storage and disposal is subject to regulation at the enzymatic level on a minute-to-minute time scale, while enzyme levels are subject to transcriptional regulation, on a longer time scale.

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Angiostatin by Icon Group International


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